So, here's the deal
I'm AFK farming secret letters, swell, now they auto complete in under 3 seconds! Great!
But the thing is, depending on where I'm standing, characters like Psyche, Lady Nifle, even Fushu (which "was made" to be a companion and not a main character) sometimes stop attacking altogether!
And don't get me started on spawns!
Sometimes spawns stop too!
Also, I had a run that I stopped collecting the rewards standing right next to it, with max bro boxie.
It has happened only once, restarting the level fixed. I'll try to replicate the issue.
Hopefully a Dev sees this and tell us how they plan to fix this (hopefully) in the near future.

NotNameless
how and where do you farm secret letter?
Funtinari
Yea I had a demon wedge run enemies stopped spawning about 41/150 enemies. Ran around the entire zone, nothing.